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Is this why you feel achy in the morning?

Netdoctor logo Netdoctor 2017-04-21 Karen Gordon

Why you feel achy in the morning © Cornelia Schauermann / Gallery Why you feel achy in the morning According to scientists, we wake up feeling sore in the mornings because the body's natural painkiller has not kicked in yet. They suggest that the reason our limbs can feel rigid and ache when we wake up is because the body's 'biological clock' suppresses anti-inflammatory proteins during sleep.

The scientists at Manchester University found a type of protein called cryptochrome blocks biological pathways controlling inflammation during night-time sleep, delaying symptoms and then making it feel worse when we wake up and start moving around each morning. The new research could help find new drugs to treat diseases such as arthritis.

Dr Julie Gibbs, a researcher at the Centre for Endocrinology and Diabetes at the University of Manchester's Institute of Human Development, said: "By understanding how the biological clock regulates inflammation, we can begin to develop new treatments, which might exploit this knowledge. Furthermore, by adapting the time of day at which current drug therapies are administered, we may be able to make them more effective."

Dr Gibbs and her team harvested cells from joints of healthy mice and humans and altered those cells' natural 24-hour rhythms by knocking out the cryptochrome protein gene. This led to an increased inflammatory response suggesting its product, the cryptochrome protein has significant anti-inflammatory effects.

© Provided by National magazine company ltd (Hearst UK) The scientists also exposed arthritic mice to constant light and found that they had no daily variation in inflammation as normally seen.

Stephen Simpson, director of research and programmes Arthritis Research UK, says that this research is very interesting and represents significant progress in our understanding how our internal 'body clock' regulates inflammation and thus pain associated with this.

He says, "Many people with arthritis report that their joints are more stiff in the morning, and the results of this study reveal a likely biological basis to this effect. It's a very exciting prospect that it may be possible to use this new information to improve treatments and pain relief for people affected by arthritis. At Arthritis Research UK we know that living in pain, day in and day out, can have a devastating impact on people's lives, affecting their independence, mobility and ability to stay in work. Anyone worried about their joint pain and seeking information and tips to manage their condition more effectively, can order our new Joint Pain Relief guide available now. We would also recommend that people speak to a health care professional to discuss the most appropriate pain management option for them."

The research was published in the Federation of American Societies for Experimental Biology journal.

Related: Tips For Developing A Morning Routine (Provided by Wochit News)

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