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Human head transplant scientist says promising animal studies mean first procedure could take place next year

The Independent The Independent 21/09/2016 Adam Withnall

First human head transplant procedure ‘could take place next year’ © The Independent First human head transplant procedure ‘could take place next year’
An Italian scientist who wants to be the first neurosurgeon to conduct a human head transplant says the procedure could be possible as early as next year, after three promising new animal studies.

Sergio Canavero says three new papers, all edited by him and published on Tuesday in the journal Surgical Neurology International, show it is possible to overcome one of the biggest hurdles to attaching a new body to a human head - reconnecting the spinal cord.

Critics say the three studies do not have the breadth of data or the detail to warrant moving forward with tests in humans.

But the South Korean team involved in conducting the experiments say they provide valuable proof of the principle that a chemical solution, injected into the spinal cord, can encourage severed neurons to reattach.

The most extraordinary of the case studies involved a dog which had become completely paralysed after a neck injury caused severe damage to the spine.

Doctor C-Yoon Kim and his team at Konkuk University in Seoul, which has been working with Canavero, said 90 per cent of the dog's spinal cord was estimated to have been cut.

According to the paper, they injected the dog with the chemical solution polyethylene glycol or PEG, and after two days it was able to move its front paws.

A video of the dog's progress showed that after two weeks, it was able to drag its hind limbs by its torso and forelimbs. According to New Scientist, which has seen the video, during the third week it was able to walk. 

In another study, the South Korean team severed the spinal cords of 16 mice. Half of them were given the PEG solution, and five of those eight showed signs of regaining movement. The other three died, as did all of the control group, none of which recovered from the paralysis.

And in the final study, five out of a group of 10 rats were given a PEG solution enhanced with graphene nanoribbons - in theory, providing a sort of scaffold along which the neurons can grow back. The team said a flood at the lab killed four of the five PEG-dosed rats, though the fifth recovered the ability to walk.

Experts in the field have said the rat and mice studies did not involve sufficient numbers to be convincing - particularly the experiment hit by flooding. There are also suggestions the team did not provide enough detail of the specific injuries suffered by the dog before its treatment and apparent recovery.

But alongside the risk of the body rejecting its new head, reconnecting the spinal cord is one of the biggest challenges preventing human head transplants from taking place.

Canavero believes that with the promise of PEG, he could perform the procedure by the end of 2017. A hospital in Vietnam says it is willing to host the surgery - he says he just needs a viable donor.

Yet speaking to New Scientist, medical ethicist Arthur Caplan at New York University said the latest papers suggest we are still a long way off even contemplating such a transplant.

“This work would put them about three or four years from repairing a spinal cord in humans,” he said. “It would put them maybe seven or eight from trying anything like a head transplant.”

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