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No One Is Prepared for Hagfish Slime

The Atlantic logo The Atlantic 1/23/2019 Ed Yong
a car parked on pavement near a forest: A car is covered in hagfish, and slime, after an accident on Highway 101. © Reuters A car is covered in hagfish, and slime, after an accident on Highway 101.

At first glance, the hagfish—a sinuous, tubular animal with pink-grey skin and a paddle-shaped tail—looks very much like an eel. Naturalists can tell the two apart because hagfish, unlike other fish, lack backbones (and, also, jaws). For everyone else, there’s an even easier method. “Look at the hand holding the fish,” the marine biologist Andrew Thaler once noted. “Is it completely covered in slime? Then, it’s a hagfish.”

Hagfish produce slime the way humans produce opinions—readily, swiftly, defensively, and prodigiously. They slime when attacked or simply when stressed. On July 14, 2017, a truck full of hagfish overturned on an Oregon highway. The animals were destined for South Korea, where they are eaten as a delicacy, but instead, they were strewn across a stretch of Highway 101, covering the road (and at least one unfortunate car) in slime.

Typically, a hagfish will release less than a teaspoon of gunk from the 100 or so slime glands that line its flanks. And in less than half a second, that little amount will expand by 10,000 times—enough to fill a sizable bucket. Reach in, and every move of your hand will drag the water with it. “It doesn’t feel like much at first, as if a spider has built a web underwater,” says Douglas Fudge of Chapman University. But try to lift your hand out, and it’s as if the bucket’s contents are now attached to you.

The slime looks revolting, but it’s also one of nature’s more wondrous substances, unlike anything else that’s been concocted by either evolution or engineers. Fudge, who has been studying its properties for two decades, says that when people first touch it, they are invariably surprised. “It looks like a bunch of mucus that someone just sneezed out of their nose,” he says. “That’s not at all what it’s like.”

Read: [The brainless slime that shares memories by fusing]

For a start, it’s not sticky. If there wasn’t so damn much of it, you’d be able to wipe it off your skin with ease. The hagfish themselves scrape the slime off their skin by tying a knot in their bodies and sliding it from head to tail.

The slime also “has a very strange sensation of not quite being there,” says Fudge. It consists of two main components—mucus and protein threads. The threads spread out and entangle one another, creating a fast-expanding net that traps both mucus and water. Astonishingly, to create a liter of slime, a hagfish has to release only 40 milligrams of mucus and protein—1,000 times less dry material than human saliva contained. That’s why the slime, though strong and elastic enough to coat a hand, feels so incorporeal.

Indeed, it’s one of the softest materials ever measured. “Jell-O is between 10,000 and 100,000 times stiffer than hagfish slime,” says Randy Ewoldt from the University of Illinois at Urbana-Champaign, who had to invent new methods for assessing the substance’s properties after conventional instruments failed to cope with its nature. “When you see it in a bucket, it almost still looks like water. Only when you stick your hand in and pick it up do you find that it’s a coherent thing.”

The proteins threads that give the slime cohesion are incredible in their own right. Each is one-100th the width of a human hair, but can stretch for four to six inches. And within the slime glands, each thread is coiled like a ball of yarn within its own tiny cell—a feat akin to stuffing a kilometer of Christmas lights into a shoebox without a single knot or tangle. No one knows how the hagfish achieves this miracle of packaging, but Fudge just got a grant to test one idea. He thinks that the thread cells use their nuclei—the DNA-containing structures at their core—like a spindle, turning them to wind the growing protein threads into a single continuous loop.

A microscope image of a hagfish’s coiled slime thread (Courtesy of Douglas Fudge) © Provided by Atlantic Media, Inc. A microscope image of a hagfish’s coiled slime thread (Courtesy of Douglas Fudge)

Once these cells are expelled from the slime glands, they rupture, releasing the threads within them. Ewoldt’s colleague Gaurav Chaudhury found that despite their length, the threads can fully unspool in a fraction of a second. The pull of flowing water is enough to unwind them. But the process is even quicker if the loose end snags on a surface, like another thread, or a predator’s mouth.  

Being extremely soft, the slime is very good at filling crevices, and scientists had long assumed that hagfish use it to clog the gills of would-be predators. That hypothesis was only confirmed in 2011, when Vincent Zintzen from the Museum of New Zealand Te Papa Tongarewa finally captured footage of hagfish sliming conger eels, wreckfish, and more. Even a shark was forced to retreat, visibly gagging on the cloud of slime in its jaws.

“We were blown away by those videos,” Fudge says, “but when we really looked carefully, we noticed that the slime is released after the hagfish is bitten.” So how does the animal survive that initial attack? His colleague Sarah Boggett showed that the answer lies in their skin. It’s exceptionally loose, and attaches to the rest of the body at only a few places. It’s also very flaccid: You could inject a hagfish with an extra 40 percent of its body volume without stretching the skin. The animal is effectively wearing a set of extremely loose pajamas, Fudge says. If a shark bites down, “the body sort of squishes out of the way.”

Read: [Mysterious ocean blobs aren’t so mysterious]

That ability makes hagfish not only hard to bite, but also hard to defend against. Calli Freedman, another member of Fudge’s team, showed that these animals can wriggle through slits less than half the width of their bodies. In the wild, they use that ability to great effect. They can hunt live fish by pulling them out of sandy burrows. And if disturbed by predators, they can dive into the nearest nook they find. Perhaps that’s why, in 2013, the Italian researcher Daniela Silvia Pace spotted a bottlenose dolphin with a hagfish stuck in its blowhole.

More commonly, these creatures burrow into dead or dying animals, in search of flesh to scavenge. They can’t bite; instead, they rasp away at carcasses with a plate of toothy cartilage in their mouths. The same traveling knots they use to de-slime themselves also help them eat. They grab into a cadaver, then move a knot from tail to head, using the leverage to yank out mouthfuls of meat. They can also eat by simply sitting inside a corpse, and absorbing nutrients directly through its skin and gills. The entire hagfish is effectively a large gut, and even that is understating matters: Their skin is actually more efficient at absorbing nutrients than their own intestines.

a pile of hot dogs: Hagfish on display at a seafood market (Elizabeth Beard / Getty) © Provided by Atlantic Media, Inc. Hagfish on display at a seafood market (Elizabeth Beard / Getty)

Hagfish are so thoroughly odd that biologists have struggled to clearly work out how they’re related to other fish, and to the other backboned vertebrates. Based on their simple anatomy, many researchers billed them creatures as primitive precursors to vertebrates—an intermediate form that existed before the evolution of jaws and spinal columns.

But a new fossil called Tethymyxine complicates that story. Hailing from a Lebanese quarry, and purchased by researchers at a fossil show in Tuscon, Arizona, the Cretaceous-age creature is clearly a hagfish. It has a raspy cartilage plate in its mouth, slime glands dotting its flanks, and even chemicals within those glands that match the composition of modern slime. By comparing Tethymyxine to other hagfish, Tetsuo Miyashita from the University of Chicago concluded that these creatures (along with another group of jawless fish, the lampreys) are not precursors to vertebrates, but actual vertebrates themselves.

Such work is always contentious, but it fits with the results of genetic studies. If it’s right, then hagfish aren’t primitive evolutionary throwbacks at all. Instead, they represent a lineage of vertebrates that diverged from all the others about 550 million years ago, and lost several traits such as complex eyes, taste buds, scales, and perhaps even bones. Maybe those losses were adaptations to a life spent infiltrating carcasses in the dark, deep ocean, much like their flaccid, nutrient-absorbing skins are. “Hagfishes might look primitive, they’re actually very specialized,” Miyashita adds.

Their signature slime might also evolved as a result of that lifestyle, as a way of fending off predators that were competing for cadavers. “Everything about hagfish is weird,” says Fudge, “but it all kind of fits.”  

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