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Charlotte vs. FIU odds, point spread: 2021 college football picks, Week 6 predictions from model on 12-4 run

CBS Sports logo CBS Sports 10/8/2021 CBS Sports Staff
Dec 20, 2019; Frisco, TX, USA; Kent State Golden Flashes quarterback Dustin Crum (14) runs the ball against Utah State Aggies safety Troy Lefeged Jr. (3) during the first quarter during the Frisco Bowl at Toyota Stadium. © Provided by CBS Sports

Dec 20, 2019; Frisco, TX, USA; Kent State Golden Flashes quarterback Dustin Crum (14) runs the ball against Utah State Aggies safety Troy Lefeged Jr. (3) during the first quarter during the Frisco Bowl at Toyota Stadium.

Charlotte (3-2) is 1-0 in conference play and will look to stay that way after Week 6 of the 2021 season. The 49ers will visit FIU (1-4) on Friday in a Conference USA matchup. The Panthers have never lost the 49ers and are riding a five-game winning streak against them. The visitors have been more successful this year and could turn the tide, though.

Kickoff at Riccardo Silva Stadium is set for 7 p.m. ET on CBS Sports Network. The 49ers are listed at -3.5 in the latest Charlotte vs. FIU odds from Caesars Sportsbook, while the over-under for total points scored is 60.5. Before locking in any FIU vs. Charlotte picks or college football predictions, you need to see what the proven SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Charlotte vs. Florida International and just revealed its CFB picks and predictions. You can visit SportsLine now to see all of the model's college football picks. Here are the college football odds and betting lines for Florida International vs. Charlotte:

  • Charlotte vs. FIU spread: Charlotte -3.5 
  • Charlotte vs. FIU over-under: 60.5 points  
  • Charlotte vs. FIU money line: Charlotte -170, FIU +145
  • CLT: The total has gone under in four of Charlotte's last five games 
  • FIU: The Panthers are 5-0 straight up in their previous five games against the 49ers
Featured Game| FIU Panthers vs. Charlotte 49ers

Why Charlotte can cover

Charlotte has been a pleasant surprise in 2021. The 49ers topped Duke on the road in their season opener before blowing out Gardner-Webb the following week. While the Panthers are looking to extend a five-game winning streak against the 49ers, their porous secondary could make that challenging.

FIU has lost four straight games and gave up more than 300 passing yards in three of those matchups. Victor Tucker and Grant DuBose have been quality targets out wide so far this season. The pair could wreak havoc on a Panthers defense that's struggled to defend against the pass. Tucker and Dubose have combined for 47 receptions, 733 yards, and five touchdowns so far. 

Why FIU can cover

Charlotte has pulled off some impressive wins this year but has yet to put it all together on the road. It has lost four of its last five home games. The 49ers' two road losses this year have been by double-digits. They could need a big turnaround to end their recent slide.

The Panthers have been highly productive on offense. This season, two Panthers receivers have eclipsed 400 receiving yards, and quarterback Max Bortenschlager ranks 17th in the NCAA in passing yards. D'Vonte Price has rushed for 411 yards and six scores in 2021. He's crossed the century mark in two games and could thrive against a 49ers defense that gave up more than 250 rushing yards to a single Illinois back last week. 

How to make Charlotte vs. FIU picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 61 points. It also has generated an against-the-spread pick that cashes in almost 60 percent of simulations. You can only get the model's Charlotte vs. FIU ATS pick at SportsLine.

So who wins Charlotte vs. FIU? And which side of the spread cashes almost 60 percent of the time? Visit SportsLine now to see which side of the FIU vs. Charlotte spread to back, all from the advanced model that is up almost $3,300 on its top-rated college football spread picks, and find out.


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