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49ers QB Jimmy Garoppolo misses practice again; Trey Lance to start at Cardinals?

Yardbarker logo Yardbarker 10/8/2021 Zac Wassink, Yardbarker
San Francisco 49ers quarterback Jimmy Garoppolo. © Darren Yamashita-USA TODAY Sports San Francisco 49ers quarterback Jimmy Garoppolo.

All indications are that San Francisco 49ers starting quarterback Jimmy Garoppolo won't be good to go for Sunday's showdown with the undefeated Arizona Cardinals because of the calf contusion he suffered in last Sunday's loss to the Seattle Seahawks that dropped the Niners to 2-2. 

Whether or not Garoppolo returns to the lineup when he's healthy will have to be seen. 

According to ESPN's Adam Schefter and others, Garoppolo missed practice for the third consecutive day because of his latest setback: 

Rookie and third overall draft pick Trey Lance, who replaced the injured Jimmy G against Seattle, is in line to start at Arizona.

Lance completed 50% (9-of-18) of his pass attempts for 157 yards and two touchdowns in the defeat to Seattle, and he added 41 rushing yards on seven carries. 


Video: Could Lance era begin after Garoppolo injury? (NBC Sports)

Replay Video

San Francisco head coach Kyle Shanahan has repeatedly said since the spring he planned to start a healthy Garoppolo over Lance so that the first-year pro could learn about life in the NFL from the sidelines, and the 49ers have a bye week before they return to action against the Indianapolis Colts on Oct. 24. 

Of course, Chicago Bears head coach Matt Nagy made similar statements about veteran Andy Dalton and rookie Justin Fields earlier this year before Dalton went down to a knee injury last month. 

Nagy named Fields his QB1 moving forward on Wednesday. 

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