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Opinion: 20 most devastating losses in NFL history

Touchdown Wire Logo By Andy Nesbitt of Touchdown Wire | Slide 3 of 21: Getty

19. RG3, Redskins crumble in home playoff game

Rookie QB Robert Griffin III leading the 2012 Washington Redskins to a 10-6 and their first playoff appearance since 2007. Hopes were extremely high in D.C. as fans thought they had found their franchise QB who would bring them back to their Super Bowl winning days. But then it quickly all went horribly wrong against the Seahawk - the Redskins not only lost at home but RG3 suffered a knee injury that he would never really rebound from.

© David E. Klutho /Sports Illustrated/Getty Images

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