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Nobel Prize for 3 chemists who made molecules ‘click’

SHOTLIST:RESTRICTION SUMMARY:ASSOCIATED PRESSStockholm – 5 October 20221. Various of the Royal Swedish Academy of Sciences news conferenceANNOTATION: Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless won the Nobel Prize in chemistry.TEXT: The three scientists were awarded for developing a way of "snapping molecules together" that can be used to design better medicines.ASSOCIATED PRESSPalo Alto, California - 5 October 20222. SOUNDBITE (English) Carolyn Bertozzi, Nobel Prize winner for chemistry: ++PARTIALY COVERED++"It took a while, it took a few minutes for me to comprehend that it wasn't some hallucination or strange dream, you know. And in fact, it was the chair of the Nobel Committee."3. Bertozzi looking at her phone in her apartment4. SOUNDBITE (English) Carolyn Bertozzi, Nobel Prize winner for chemistry: ++PARTIALY COVERED++"We use these chemistries to study biological molecules in cells, in living organisms, and also to develop new kinds of medicines for diseases like cancer."ASSOCIATED PRESSCopenhagen - 5 October 20225. Nobel Prize winner Morten Meldal being cheered and receiving flowers6. SOUNDBITE (English) Morten Meldal, Nobel Prize winner in Chemistry 2022: ++PARTIALY COVERED++"I did not expect it at all. It was actually a complete surprise. I was sitting in my office working with teaching material, when I was called by the Nobel Committee with the message that I would share the prize this year with Caroline Bertozzi and Barry Sharpness. And so it happens that they are good friends of mine. So that's very nice."7. Wide of crowd8. Wide of Meldal standing with flowers9. SOUNDBITE (English) Morten Meldal, Nobel Prize winner in Chemistry 2022: ++PARTIALY COVERED++"I think it's very important that we get more young people to choose chemistry, which is a little bit difficult at the moment because chemistry is the solution to many of our challenges."10. Meldal standing with flowersSTORYLINE:Three scientists were jointly awarded this year's Nobel Prize in chemistry on Wednesday for developing a way of "snapping molecules together" that can be used to explore cells, map DNA and design drugs that can target diseases such as cancer more precisely.Americans Carolyn R. Bertozzi and K. Barry Sharpless, and Danish scientist Morten Meldal were cited for their work on click chemistry and bioorthogonal reactions."It's all about snapping molecules together," said Johan Aqvist, a member of the Royal Swedish Academy of Sciences that announced the winners at the Karolinska Institute in Stockholm.Sharpless, 81, who previously won a Nobel Prize in 2001 and is now the fifth person to receive the award twice, first proposed the idea of connecting molecules using chemical "buckles" around the turn of the millennium, Aqvist said."The problem was to find good chemical buckles," he said. "They have to react with each other easily and specifically."Meldal, 68, based at the University of Copenhagen and Sharpless, who is affiliated with Scripps Research in California, independently found the first such candidates that would easily snap together with each other but not with other molecules, leading to applications in the manufacture of medicines and polymers.Bertozzi, 55, who is based at Stanford University "took click chemistry to a new level," the Nobel panel said, by finding a way to make the process work inside living organisms without disrupting them.The goal is "doing chemistry inside human patients to make sure that drugs go to the right place and stay away from the wrong place," she said, speaking by phone at a news conference following the announcement.The award was a shock, she said. "I'm still not entirely positive that it's real, but it's getting realer by the minute."Bertozzi, who is paid by the Howard Hughes Medical Institute, which also supports The Associated Press' Health and Science Department, said she was grateful for the energy and enthusiasm that a Nobel Prize win will inject into the field.===========================================================Clients are reminded: (i) to check the terms of their licence agreements for use of content outside news programming and that further advice and assistance can be obtained from the AP Archive on: Tel +44 (0) 20 7482 7482 Email: they should check with the applicable collecting society in their Territory regarding the clearance of any sound recording or performance included within the AP Television News service (iii) they have editorial responsibility for the use of all and any content included within the AP Television News service and for libel, privacy, compliance and third party rights applicable to their Territory.
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