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How COVID-19 Causes Stroke with Dr. Jason Hinman

Bill Monroe logo: MainLogoBill Monroe 7/18/2022 Bill Monroe

One thing people forget when they relate this to influenza or other diseases is that this is an entirely new #coronavirus infecting humans.   — @HinmanLabsUCLA #Stroke #COVID-19 #Research

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We know that COVID-19 causes stroke in many cases. You can recover from the disease and then still have a stroke caused by the virus. Sometimes the only way you find out you have a COVID-19 infection is that you go to the hospital with a stroke and they tell you. In the US, about 1500 strokes a week are caused by COVID-19.

But why is this happening?

We’re starting to get some answer about how COVID-19 causes stroke thanks to the work of Dr. Jason Hinman and his colleagues at the University of California Los Angeles (UCLA). In this episode Jason and I talk about his research and the relationship between Stroke and COVID-19.

If you don’t see the audio player below, visit http://Strokecast.com/Jason to listen to the conversation.

Bio

Dr. Jason Hinman poses for a professional headshot in his white coat. © Provided by Bill Monroe Dr. Jason Hinman poses for a professional headshot in his white coat.

Jason Hinman, M.D., Ph.D. – Dr. Hinman is Assistant Professor of Neurology at the David Geffen School of Medicine and Interim Director of the Stroke Program at the West Los Angeles VA Medical Center. Dr. Hinman received his MD/PhD degrees from Boston University School of Medicine.

He completed adult neurology residency training at Ronald Reagan UCLA Medical Center with fellowship training in vascular neurology and stroke rehabilitation also at UCLA. His NIH-funded research laboratory focuses on the molecular pathways at the interface of stroke and Alzheimer’s dementia using basic and translational models of stroke and cerebrovascular disease. 

What has always troubled me as a physician is the randomness of #stroke.   — @HinmanLabsUCLA  #COVID-19 #Research

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The Model

The technology Jason, Dr. Naoki Kaneko,  and their colleagues use is fascinating. They’ve taken scans (MRIs, CT scans, Angiograms, etc.) of patients’ brains and used those scans to build a physical, 3-D model of the networks of veins and arteries in the brain. This allows them to see just how blood flows and where it struggles.

It also means neurosurgeons who may be planning to fix a patient’s aneurysms with a stent or coil could practice on an actual model before going into the patient’s brain.

With Jason’s research, they line the fake vessels in their model with human epithelial cells. These cells are the same ones that line our real blood vessels. As a result, they were able to observe the way the virus interacts with the blood vessels. Then they learn how that interaction can lead to clots and other blood vessel damage, which, in turn, causes a stroke.

Here’s a link to the study: https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.120.032764

And here’s a link to the press release about the study: https:/newsroom.ucla.edu/releases/covid-19-increased-stroke-risk

So it's really just fortunate that we were poised to do the work at the right time, and it seemed like to us very logical to flip this technology into a study of the problem of the day.  — @HinmanLabsUCLA #Stroke #COVID-19 #Research

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The Solution

If you’ve survived a COVID-19 infection, how can you reduce your chances of having a stroke? Right now, the best research says to eat right, exercise, hydrate, and get good sleep.

In other words, do the things the medical establishment has been telling us to do for years. There’s no magic solution. We just have to do the hard work of doing the right thing. Which, of course, is also how you reduce your chances of having a stroke even if you haven’t had COVID.

I know. It sucks. But at least it’s cheap.

[Preventing #stroke] means recognizing the value of sleep, healthy eating, hydration, exercise.  — @HinmanLabsUCLA #COVID-19 #Research

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BEFAST

More people are having stroke due to COVID-19. Younger people are having strokes. Many of these strokes can be treated and result in minimal disability if the person gets to the right hospital quickly enough.

So make sure everyone you know can recognize a stroke. Teach them to BEFAST.

Sudden loss or change in Balance, Eyesight, Facial droop, Arm control, Speech or language means that it is Time to call an ambulance.

Stroke symptom graphic © Provided by Bill Monroe Stroke symptom graphic

And if necessary, we can treat [#stroke] patients in ambulances, in hallways. We can't do that if you're not here.  — @HinmanLabsUCLA #COVID-19

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The Important Takeaway

Don’t catch COVID-19.

The impacts are long lasting. Even if you survive (and most people will) it still damages your blood vessels, your heart, your kidneys, your lungs, and more. If you survive, the Grim Reaper gets another bite at that apple through COVID inspired stroke and other conditions.

Mask up when you go outside. The mask isn’t to protect you. It’s to protect anyone else that you see and their families. The fact is there is no way to know for sure if you are infected right now. You could be. I could be. Since symptoms may not show up for a couple weeks, we can’t know. Mask up so you don’t kill someone or give them a stroke.

Minimize social contact. When you do have that contact, keep your distance. Avoid crowded indoor spaces. If you see someone without a mask, stay away from them. If they get offended, so what? Let them. Afterall they’re the ones trying to infect and kill you.

Take advantage of delivery and curbside pickup. Work from home if you can.

Not everyone has those options. Respect people who do have to go out to work by respecting rules intended to reduce transmission.

Many of us don’t have to stay locked up 24-7 for months on end. We can go out on occasion, but we have to be responsible about it.

Mask up, get a vaccine and try to stay out of the hospital.  — @HinmanLabsUCLA #Stroke #COVID-19 #Research

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Hack of the Week

It’s winter, my Dysport (Botox alternative) is wearing off, and we’ve had a stressful start to 2021. All that adds up to my tone and spasticity getting stronger and tighter.

When I want to undo that fist I make by default, I could just forcefully  open my fingers, but that just encourages more resistance.

What’s for effective is to bend my wrist down (flexion) in the direction the wrist tone want to go anyway. When you bend your wrist down, that naturally encourages your fingers to open up.

The reason for that is that the finger extensors — the muscles that open your fingers run from your forearm over the top of your wrist and the back of your hand. Bending your wrist down causes them to pull on your fingers, opening your fist.

Give it a try.

I see patients who stay #motivated are much more likely to have a #recovery.  — @HinmanLabsUCLA #Stroke #COVID-19 #Research

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Links

Dr. Jason Hinman on Twitter

Dr. Jason Hinman on UCLA Health

Dr. Jason Hinman on LinkedIn

Dr. Jason Hinman on Research Gate

Hinman Lab

Dr. Naoki Kaneko on Muck Rack

Research Press Release

Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

David Geffen School of Medicine

VA Greater Los Angeles Healthcare System

Ronald Reagan UCLA Medical Center

Boston University School of Medicine

Despite media reports of overwhelmed hospitals, it's critical to seek the appropriate and urgent medical care when having symptoms of a #stroke.  — @HinmanLabsUCLA  #BEFAST 

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Where do we go from here?

Many patients are at risk, but a good fraction are otherwise healthy and yet struck down by this really challenging disease [#stroke]. And in many cases doesn't kill, but rather disables.  — @HinmanLabsUCLA #COVID-19 #Research

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Strokecast is the stroke podcast where a Gen X stroke survivor explores rehab, recovery, the frontiers of neuroscience and one-handed banana peeling by helping stroke survivors, caregivers, medical providers and stroke industry affiliates connect and share their stories.

Bill Monroe is not a doctor or medical professional of any sort. He’s just a marketing guy who now knows way more about neurology and neuroplasticity than any marketing guy should know.

Bill and Bill’s guests provide general information, personal stories, education starting points and entertainment. They do not provide medical advice. Do not make any changes to your treatment plan or the execution of your treatment plan without discussing it with your doctor or personal medical team.

*Affiliate links

Affiliate links link to products and service where Bill may earn some compensation if you place an order. This does not affect the price you pay.

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