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Biogen (BIIB) Q3 2016 Results - Earnings Call Transcript

Seeking Alpha logo Seeking Alpha 10/26/2016 SA Transcripts

Biogen, Inc. (BIIB)

Q3 2016 Earnings Call

October 26, 2016 8:30 am ET


Matthew Calistri - Biogen, Inc.

George A. Scangos - Biogen, Inc.

Michael D. Ehlers - Biogen, Inc.

Michel Vounatsos - Biogen, Inc.

Paul J. Clancy - Biogen, Inc.

Alfred W. Sandrock - Biogen, Inc.


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Eric Schmidt, Ph.D. - Cowen & Co. LLC

Geoff Meacham - Barclays Capital, Inc.

Geoffrey C. Porges - Leerink Partners LLC

Aaron Gal - Sanford C. Bernstein & Co. LLC

Brian Abrahams - Jefferies LLC

Michael Yee - RBC Capital Markets LLC

Ying Huang - Bank of America Merrill Lynch

Matthew K. Harrison - Morgan Stanley & Co. LLC

John Scotti - Evercore Group LLC

Robyn Karnauskas - Citigroup Global Markets, Inc. (Broker)

Christopher Raymond - Raymond James & Associates, Inc.

Cory W. Kasimov - JPMorgan Securities LLC



Good morning. My name is Dan, and I will be your conference operator today. At this time, I would like to welcome everyone to the Biogen third quarter 2016 financial results and business update. All lines have been placed on mute to prevent any background noise. After the speakers' remarks, there will be a question-and-answer session.

Thank you. I now would like to turn the conference over to Matthew Calistri, Senior Director of Investor Relations. You may begin your conference.

Matthew Calistri - Biogen, Inc.

Thank you, Dan, and welcome, everyone, to Biogen's third quarter 2016 earnings conference call.

Before we begin, I encourage everyone to go to the Investors section of to find the press release and related financial tables, including a reconciliation of the GAAP to non-GAAP financial measures that we'll discuss today. Our GAAP financials are provided in Tables 1 and 2. Table 3 includes a reconciliation of our GAAP to non-GAAP financial results. We believe non-GAAP financial results better represent the ongoing economics of our business and reflect how we manage the business internally. We have also posted slides on our website that follow the discussions related to this call.

I would like to point out that we will be making forward-looking statements which are based on our current expectations and beliefs. These statements are subject to certain risks and uncertainties, and our actual results may differ materially. I encourage you to consult the risk factors discussed in our SEC filings for additional detail.

On today's call, I'm joined by our Chief Executive Officer, Dr. George Scangos; Dr. Michael Ehlers, EVP of Research and Development; our Chief Commercial Officer, Michel Vounatsos; and our CFO, Paul Clancy. We'll also be joined for the Q&A portion of the call by our Chief Medical Officer, Dr. Al Sandrock.

Now I'll turn the call over to George.

George A. Scangos - Biogen, Inc.

Okay. Thanks, Matt, and good morning, everyone. Thanks for joining us today.

I'm happy to say Biogen delivered another solid quarter, complete with strong financial performance and significant advancements in the pipeline. For the third quarter of 2016, Biogen generated a record $3 billion in revenues, a 6% increase from the same period a year ago. Our GAAP earnings were $4.71 per share, a 13% increase versus Q3 last year. and non-GAAP earnings were $5.19 per share, a 16% increase.

I'll come back to the financials in a minute, but first I'd like to highlight some of the important third quarter pipeline progress.

One of the most exciting milestones this quarter was the positive interim analysis of nusinersen in the ENDEAR study. Recognizing the tremendous need in the SMA community, we moved quickly, established the Expanded Access program, and completed the NDA filing with the FDA in less than two months, the fastest filing time in Biogen's 38-year history. We continue to be grateful to the patients, families, investigators, and employees who worked tirelessly to bring this program to this point.

We've also filed with the EMA, where nusinersen has received Accelerated Assessment status. If approved, nusinersen would be the first treatment for patients with spinal muscular atrophy, a leading genetic cause of death in infants.

We were honored when one of our key pipeline programs was featured on the cover of Nature, specifically, the results of our preclinical research and Phase 1b study of aducanumab. This rare distinction was a first for Biogen research and one that I think further highlights the important work that we're doing in the area of Alzheimer's disease. We also announced that aducanumab was granted Fast Track designation by the FDA.

Our commercial business continued to deliver solid results this quarter. We furthered our leadership in MS through the launch of ZINBRYTA in collaboration with AbbVie, and we continued to grow the number of patients benefiting from our full portfolio of MS products.

Our third quarter hemophilia revenues grew to $217 million, and we've made further progress with the spinoff of our hemophilia business into a separate, independent, publicly traded company, known as Bioverativ, with the initial filing of the Form 10 in August. We continue to expect to complete that transaction in early 2017.

In Europe, we doubled our biosimilars revenues over the prior quarter, as BENEPALI continues to launch in markets across the continent and pick up share at a rate previously unseen for a biosimilar anti-TNF. And we launched FLIXABI, our biosimilar of infliximab. We continue to believe that our work in biosimilars is an important growth opportunity for Biogen.

So we've seen great progress in both our pipeline and our commercial portfolio during the quarter. As you'll hear shortly from Mike and Michel, our entire executive leadership team is focused on driving commercial performance, prioritizing our assets, advancing our clinical programs, and reshaping our pipeline. And our 7,000 employees globally remain committed to delivering therapies that we believe can make a positive difference in the lives of patients.

I'll now turn the call over to Mike so that he can give you a thorough update on our pipeline.

Michael D. Ehlers - Biogen, Inc.

Thank you, George, and good morning, everyone. Let me provide some highlights from this quarter, starting with multiple sclerosis.

Last month at ECTRIMS, we presented clinical findings from our broad portfolio of MS therapies as well as top line results for opicinumab, or anti-LINGO, a potential neuroreparative therapy for people with relapsing forms of multiple sclerosis.

We presented real-world data and clinical evidence showing that TECFIDERA consistently demonstrates strong efficacy by reducing MS disease activity in patients that have had up to 9 years of treatment. These data also affirm TECFIDERA's well characterized safety profile. Importantly, we believe these findings provide additional support for the early use of TECFIDERA to improve patient outcomes.

Data were also presented for ZINBRYTA, our newly launched once-monthly, self-administered subcutaneous treatment option for relapsing forms of MS. A new post-hoc analysis from the pivotal DECIDE study showed that a significantly greater number of people treated with ZINBRYTA showed no evidence of disease activity compared to those taking intramuscular interferon. Additional new interim data from the long-term extension study, EXTEND, show that treatment with ZINBRYTA had long-term benefits in the proportion of patients who remained relapse-free as well as those who did not experience 24-week confirmed disability progression.

For opicinumab, we presented top line results from the Phase 2 SYNERGY study in MS, in which opicinumab missed the primary endpoint. However, we believe the robust design of this study has allowed us to identify an appropriate patient population and dose to move forward with development. Within the 10 milligram per kilogram dosing arm of the study, we identified a treatment effect in patients whose MRI scans had specific features suggesting evidence of reduced myelination and intact axons at study entry. This subset represented approximately 1/4 of all patients in the SYNERGY study. Based on these data, we hypothesize that patients with similar features may have the potential to benefit from treatment with opicinumab. We are in the final stages of designing the next study and look forward to providing an update in the coming months.

Turning to another late-stage asset, we made significant progress advancing nusinersen this quarter. As George highlighted, in August Biogen and Ionis announced that we met the pre-specified primary endpoint upon interim analysis of ENDEAR. In the analysis, patients with infantile onset SMA, or SMA consistent with Type 1, who were treated with nusinersen demonstrated a highly statistically significant and clinically meaningful improvement in the achievement of motor milestones as measured by the Hammersmith Infant Neurological Examination. The responder analysis looked at achievement of tangible milestones like kicking, head control, rolling, sitting, crawling, standing, and walking. And we believe the results provide a real demonstration of the value nusinersen could bring for patients and their families. Data from the other endpoints analyzed were also consistently in favor of the treated infants.

The ENDEAR study remains ongoing and will be stopped once enrolled patients complete their next office visit, where it is anticipated to happen for all patients before the end of the year. Once this occurs, we will be able to provide more detailed efficacy data, including an analysis on survival.

During the quarter, we also successfully completed the rolling submission of the New Drug Application to the FDA for nusinersen. The U.S. filing was submitted less than two months after the positive interim analysis of the ENDEAR trial, a significant accomplishment for the company and recognition of the urgent need in this community. We have applied for Priority Review, which if granted will shorten the review period for nusinersen following the agency's acceptance of the filing.

Earlier this month, we also filed a Marketing Authorization Application to the European Medicines Agency. The EMA's Committee for Medicinal Products for Human Use has granted nusinersen Accelerated Assessment status, which can also reduce the standard review time. And we look forward to working with both agencies over the coming months to bring this treatment to patients as quickly as possible.

For nusinersen, our regulatory submissions are comprised of results from the pre-specified interim analysis of ENDEAR as well as all other clinical and preclinical data currently available, including open-label data in both Types 2 and 3 SMA patients. We are seeking a broad label for the treatment of SMA in our current filing applications in the U.S. and the EU.

Our other randomized placebo-controlled Phase 3 study, CHERISH, in children with later-onset SMA consistent with Type 2, was fully enrolled in March this year and remains on track for completion in the first half of 2017.

Earlier this month, we presented additional data for nusinersen at the 2016 World Muscle Society Congress in Granada, Spain. The presentations included safety results from the interim analysis of the Phase 3 ENDEAR study, which demonstrated a favorable safety profile. Analysis of the ongoing Phase 2 open-label study NURTURE demonstrated a positive effect in genetically diagnosed and pre-symptomatic SMA infants. In the NURTURE interim analysis, all 13 infants have demonstrated increases in mean Hammersmith Infant Neurological Exam scores over time, and no infants have discontinued, withdrawn from the study, or reached the primary endpoint of death or respiratory intervention in patients who have been enrolled for a minimum of 64 days and up to 13 months.

A recent analysis of data from the CS2 and CS12 open-label studies in patients with later-onset SMA, which included both Type 2 and Type 3 patients, was also presented at World Muscle. The data showed that children with SMA treated with nusinersen exhibited improvements on several measures of motor function for up to nearly three years. These results are in contrast to the stable or slow decline in scores typically observed in patients with later-onset SMA over time. We continue to be encouraged by the consistently positive results for nusinersen, which we believe support its benefit in SMA.

Now turning to Alzheimer's disease, during the quarter, a number of exciting developments occurred for our lead candidate, aducanumab. As George mentioned, results from preclinical research in the Phase 1b study of aducanumab were published in Nature, a significant achievement for the program and recognition of Biogen's high-caliber science.

Aducanumab was granted Fast Track designation by the FDA, an important step in bringing this potential therapy to patients as quickly as possible. And in a recently completed interim analysis from the Phase 1b study, which included the titration cohort Arms 8 and 9 and a portion of the long-term extension study, efficacy and safety were consistent with results previously reported and support the design of the ongoing Phase 3 ENGAGE and EMERGE studies.

The data from both the titration cohort and a portion of the long-term extension study of PRIME have been accepted to the ninth Clinical Trials in Alzheimer's Disease [CTAD] meeting in San Diego, and we look forward to sharing additional safety and efficacy data with you in December.

We're also making important progress across our pipeline, and we continue to shape our R&D engine for the future. Last year we announced an agreement to license amiselimod, an oral sphingosine 1-phosphate receptor modulator, from Mitsubishi Tanabe. Since announcing the license agreement, we assessed the compound for a number of autoimmune indications, with a particular interest in inflammatory bowel disease. As we prioritize our strategic objectives and the IBD landscape continues to evolve, we've decided to discontinue our current development plan for amiselimod.

As we mentioned last quarter, we generated encouraging Phase 1 data on BIIB059, our anti-BDCA2 for lupus. The anti-BDCA2 Phase 1 study included both healthy volunteers and a cohort of 12 lupus subjects. We anticipate presenting these data at ACR next month, including results from the lupus cohort. A Phase 2 study evaluating the efficacy and safety is BIIB059 is underway, with the first subject dose this month.

We're also working to advance BIIB074, a novel investigational state-dependent subtype selective sodium channel blocker for neuropathic pain. We have initiated an open-enrollment Phase 2b trial for lumbosacral radiculopathy, also known as sciatica. We are also close to completing enrollment in a small exploratory Phase 2a study in erythromelalgia, and we are working toward initiating a Phase 3 study in trigeminal neuralgia in 2017.

BG00011 or STX-100 for idiopathic pulmonary fibrosis [IPF] is enrolling its final cohort in a Phase 2a study, and we expect to present the data after the trial completes in the second half of next year. BG00011 blocks alpha(v)beta disintegrin, which is selectively upregulated in epithelial cells and fibrotic conditions such as IPF, and is known to be a key mediator of TGF beta activation. We believe early safety and biomarker results from this study evaluating BG00011 in IPF patients are encouraging.

In summary, we continue to make strong progress across our pipeline, and we are working aggressively to optimize and reshape our R&D activities, focusing resources to rapidly advance assets that present the greatest opportunity and address unmet need.

With that, I will now pass the call to Michel.

Michel Vounatsos - Biogen, Inc.

Thank you, Mike.

This is a solid quarter for our MS business. Our portfolio of MS therapies delivered revenues of $2.3 billion, an increase of 3% versus Q3 last year and 2% versus Q2. Excluding the impact of foreign exchange, MS revenues increased 5% versus Q3 last year and 2.5% versus Q2. Biogen maintained its global leading market share of 38% and remains the leader for both newly diagnosed and switch patients, representing the dynamic portion of the MS market.

As I communicated during our last call, the commercial organization is now focusing on four key opportunities: portfolio strategy; commercial excellence; medical leadership; trust and value. Since the beginning of Q3, we are now in execution mode, especially for MS in the U.S. With portfolio strategy, we have progressed and now identified our prioritized growth opportunities for now and 2017. It is all about making hard choices, driving consistency in resource allocation, and following through with tactical plans and execution.

With commercial excellence, in the U.S. we have piloted and defined a specific engagement model with key MS centers. The rollout is expected to be completed by year end. Additionally, we are currently enhancing our sophistication in multichannel marketing, with a strong focus on digital execution capabilities.

We need to meet our customers where they are, defined by the customer journey, to provide a seamless and differentiated Biogen engagement experience, whether through direct, digital, or other media. These are important steps, not only to improve performance in the short term, but also towards the creation of a new go-to-market model that is more effective and at a lower cost.

In terms of medical leadership, during the third quarter, our R&D colleagues have identified several key opportunities as to how to improve MS care today. We believe we have the opportunity to bring to use a regular and competitive measurement of disease progression, including cognition and imaging.

In addition, we just launched our MS Paths initiative that we believe will create a standardized high-quality data repository from the very diverse real-world patient population in the U.S. and EU. We believe this will open new and differentiated engagement opportunities with major MS clinical centers in the U.S. and in Europe.

And finally, trust and value, we are developing "beyond the pill" solutions that we believe will meet customers' day-to-day needs in living with or treating MS. We are working on establishing the leading ecosystem for patients and providers to improve patient outcomes. We believe that Biogen is the only company that has the position and commitment to MS to be able to provide this level of support in a trustworthy and valuable way.

Across these four priority areas, we have well-defined plans. And as I said, since early Q3, we are now in execution mode. Delivering on those well means enhancing the fundamental capability of the commercial operation at Biogen. These priorities are intended to not only drive performance for our inline products, but also to prepare the organization for current and future product launches.

Turning to MS performance, in the U.S., the overall MS market has experienced a 2% decline in commercial patients versus Q3 last year; while in Europe, the market continues to grow, with a 7% increase in patients versus Q3 last year. For TECFIDERA, global market share has increased by approximately 1 point to 15% versus Q3 last year. In the U.S. we had a stable TECFIDERA performance. TECFIDERA continues to capture roughly half of all patients starting on an oral, with a current oral share of 51%. And overall patient share remains relatively stable at 20% since the beginning of the year. This is a clear leadership position for all three metrics.

In Europe, there are approximately 65,000 patients on TECFIDERA, an increase of approximately 30% versus Q3 last year and approximately 4% versus Q2. TECFIDERA is now the most prescribed MS therapy in Germany, France, the UK, and Italy, with more recently launched markets continuing to drive patient growth. We do aspire to restore growth to the more mature markets, and we are very pleased to see early indicators that TECFIDERA gained share this quarter in France following two quarters of lagged performance.

Over the past year, TYSABRI has seen steady incremental share gains globally as it continues to add patients, driven by increased share in the U.S. as well as in the emerging markets. As we continue to see a shift towards increased use of high-efficacy therapies, we believe TYSABRI is benefiting from growing first-line use in the U.S.

In Europe, we are also encouraged by the recent update extending the indication for TYSABRI and allowing physicians to better optimize risk management based on JC virus antibody index values. Following the EU label approval, we have also received similar label updates in Japan, Canada, and Switzerland.

Our interferon therapies continue to play an important role amongst the injectable portion of the market. We believe PLEGRIDY is helping to slow the decline of our interferons, though it does not completely compensate for the loss of AVONEX patients.

In collaboration with AbbVie, we launched ZINBRYTA in August in the U.S. and Germany, and we just recently obtained approval in Australia. We believe the launch of ZINBRYTA comes at the right time, as we see a trend towards increased use of high-efficacy products with both current therapies and future entrants.

While early in the launch, we are encouraged by the level of physician and patient interest in the strong product profile. In the U.S., for example, over half of our target physicians have completed enrollment on our REMS [Risk Evaluation and Mitigation Strategy] program, enabling them to begin prescribing. These are early data, but we see indications that we are capturing many switching patients who otherwise might not have chosen a Biogen product. So it appears that our positioning and execution is working. Looking forward, we expect to receive reimbursement for ZINBRYTA in all the major European markets within the next 12 to 18 months.

So overall, we had a solid performance this quarter across our MS business despite the recent slowdown in the overall MS commercial market in the U.S.

We are also very excited about the continued progress of our biosimilar business. BENEPALI is now available in 13 countries. And in most markets, we are seeing a conversion rate superior to the first infliximab biosimilar launch in Europe, with up to 60% to 80% conversion in markets such as Norway or Denmark. With BENEPALI, we believe we are able to compete beyond price. We are seeing a strong preference for the BENEPALI auto-injector versus that of the originator, with our research indicating that 86% of the nurses prefer our device.

We recently also launched our infliximab biosimilar, FLIXABI, which is now available in Germany, the UK, and the Netherlands, with three additional countries anticipated in Q4. We believe our ability to potentially be the first company to offer all three major anti-TNFs in Europe could put us in a position of strength in the market. We believe biosimilars are an important growth opportunity for Biogen as we work to optimize our engagement with stakeholders across the healthcare system.

In summary, we had a very productive quarter across our MS business in terms of performance. We are encouraged with our new product launches, and we see clear progress as we work hard to elevate our commercial execution capabilities to new levels and as we improve our go-to-market model.

Also, we are particularly excited about the potential to soon launch nusinersen for SMA. With approximately 20,000 patients across the U.S., Europe, and Japan, and no available treatments today, we believe nusinersen represents a significant opportunity for both Biogen, and more importantly, for the patients who today have no treatment option.

With that, I'll turn the call over to Paul.

Paul J. Clancy - Biogen, Inc.

Thanks, Michel.

In the third quarter, our GAAP diluted earnings per share were $4.71, a 13% increase versus Q3 last year, while our non-GAAP diluted earnings per share were $5.19, an increase of 16%. Total revenue for Q3 grew 6% versus Q3 last year to approximately $3 billion.

Global third quarter TECFIDERA revenues were $1.034 billion, an increase of 10% versus Q3 of last year. This included revenues of $845 million in the U.S., an increase of 12% versus Q3 last year, and $189 million outside the U.S., an increase of 3% versus Q3 last year. In the U.S., we believe TECFIDERA benefited by approximately $40 million to $50 million versus Q2 due to inventory build in the channel. Outside the U.S., Q3 TECFIDERA decreased by $17 million versus Q2, largely driven by parallel trade dynamics. Versus Q3 last year, foreign exchange and hedge impact weakened TECFIDERA revenues by approximately $17 million.

Interferon revenues, including both AVONEX and PLEGRIDY, were $708 million during the third quarter, a decrease of 10% versus Q3 last year. This included $506 million in the U.S. and $203 million in sales outside the U.S. In the U.S., we believe there was a drawdown of AVONEX inventory in the wholesale channel, resulting in approximately $10 million versus Q2. Outside the U.S., foreign exchange and hedge impacts weakened interferon revenue by approximately $20 million versus Q3 last year.

TYSABRI worldwide revenues were $515 million this quarter, an increase of 7% versus Q3 last year. This included $301 million in the U.S. and $214 million outside the U.S. Outside the U.S., TYSABRI revenues benefited by $20 million due to a favorable adjustment to our discounts and allowances. Foreign exchange and the hedge impact weakened TYSABRI revenue by approximately $16 million versus Q3 last year.

Our hemophilia products continued to perform well this quarter. ELOCTATE revenues for the quarter were $132 million, an increase of 46% versus Q3 last year. This includes $110 million in the U.S. and $22 million outside the U.S. ALPROLIX revenues in Q3 were $85 million, an increase of 30% versus Q3 last year, including $67 million in the U.S. and $19 million outside the U.S.

Our biosimilar business generated $31 million in revenues this quarter, driven primarily by BENEPALI.

Turning to our AFICD-20 revenues, which include our profit share for RITUXAN and GAZYVA in the United States as well as our profit share and royalties on sales of rituximab outside the U.S., we recorded $318 million for Q3, a decrease from Q2, driven by a reduction in inventory from the second quarter.

Total other revenues, which include revenues from collaboration relationships, royalties, and contract manufacturing, were $99 million in the third quarter. The increase versus Q2 was related to contract manufacturing for a strategic partner, slightly offset by a $13 million loss in our AbbVie collaboration profit share.

Now turning to the expense lines on the P&L, Q3 GAAP cost of goods sold was $417 million or 14% of revenue. Non-GAAP COGS was $396 million or 13% of revenue. The increase versus Q2 was primarily attributable to a mid-single-digit royalty on U.S. sales of both AVONEX and PLEGRIDY.

Q3 GAAP and non-GAAP R&D expense was $529 million or 18% of revenue. Both GAAP and non-GAAP R&D expense included a $75 million payment to Ionis related to the exercise of our opt-in right to develop and commercialize nusinersen globally.

I'd like to note that our collaboration partner Eisai has stated their goal to start a Phase 3 trial for E2609. A $50 million milestone payment is expected to be triggered once the first patient is dosed in the E2609 Phase 3 trial, and there's a potential chance they could dose the first patient by the end of this year. The $50 million milestone was not considered in our midyear 2016 R&D guidance.

Q3 GAAP SG&A expense was $463 million. Q3 non-GAAP SG&A expense was $461 million or 16% of revenue. Other net expense was $58 million in Q3, which includes $66 million in interest expense, primarily related to our 2015 bond offering.

In Q3, both our GAAP and non-GAAP tax rates were approximately 25%. Our weighted average diluted share count was approximately $219 million for Q3, which brings us to our diluted earnings per share, which were $4.71 on a GAAP basis and $5.19 on a non-GAAP basis.

We ended the quarter with $7.4 billion in cash and marketable securities, with approximately 40% of this in the United States. During the quarter, we repurchased 1.1 million shares of the company's common stock for a total value of $349 million.

So as often, we had a number of puts and takes in the quarter, nevertheless a very solid financial quarter. I'll turn the call over to George for his closing comments.

George A. Scangos - Biogen, Inc.

Okay, thank you, Paul.

I'm very pleased with what we've accomplished this quarter. We delivered solid commercial performance, strong financial results, and important advances in the pipeline. I'm particularly excited about the direction we're heading as we finish 2016 and look forward to 2017 and beyond. As I've said, I believe we're at the beginning of a transformative era in neurodegeneration, which could result in a new era for Biogen as well. We're already starting to see the types of discoveries that can be expected as science advances and innovative trial designs yield previously unseen results and insights.

We believe the early data for aducanumab point to additional opportunities to invest in novel science to address Alzheimer's disease and other neurodegenerative diseases. The insights we've gained from the SYNERGY trial are teaching us more about remyelination, and we're enthusiastic about moving opicinumab forward. And the encouraging results we're seeing from nusinersen point to the possibility that there can be entirely new mechanisms and modalities for treating the many daunting diseases of the central nervous system.

I'm proud to have led Biogen for more than 6 years now, and it's gratifying to me to be in a position to turn a high-performing organization over to a successor. Our board search for a new CEO is progressing. We don't have a formal update on timing yet. But as you'd expect, the opportunity to lead Biogen is generating plenty of interest. And in the meantime, I'm working closely with our management team as we strive to realize our goals for 2016 and kick off a busy and productive 2017. We're fortunate to have a great leadership team and a passionate group of employees who come to work every day to make a positive impact on patients' lives, and I thank all of them for their hard work and dedication.

Thanks to all of you for joining us this morning, and we'll now open up the call for questions.

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