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Colin Firth Becomes a Dual Citizen

Scientists Discover 'Switch' for Aggressive Breast Cancer Cells

A research team from the National University of Singapore has identified a trigger that makes breast cancer cells more aggressive. In a study published in the journal Antioxidants & Redox Signaling, scientists isolated the enzyme manganese superoxide dismutase, or MnSOD, as the culprit behind invasive behavior. The study's authors say the findings open opportunities for the potential development of new breast cancer treatments. MnSOD was found to have a central role in breast cancer cell aggression, including the formation of secondary tumors. The enzyme is especially active in triple negative breast cancer, an estrogen-independent subtype of breast cancer. "By suppressing MnSOD expression or its activity in triple negative breast cancer patients, we are able to make the tumor cells less aggressive and more sensitive to chemotherapy," study author Alan Prem Kumar explained.
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