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College football odds, lines, predictions for Championship Week, 2021: Model backs Oklahoma State, Cincinnati

CBS Sports logo CBS Sports 12/2/2021 CBS Sports Staff
Derek Mason Vanderbilt © Provided by CBS Sports

Derek Mason Vanderbilt

The Championship Week college football schedule has arrived, and one matchup towers above the rest. The latest Championship Week college football odds from Caesars Sportsbook list No. 1 Georgia as a 6.5-point favorite against No. 3 Alabama in the SEC championship game at 4 p.m. ET on CBS. In a game Alabama might not be able to lose if it wants to stay in the College Football Playoff field, the point total sits at 49.5.

Elsewhere in Championship Week college football lines, No. 2 Michigan is -11 against No. 13 Iowa, No. 4 Cincinnati is -10.5 against Houston and No. 5 Oklahoma State is -5.5 against No. 9 Baylor. Which games should you target in your college football bets? Before making any college football picks for Championship Week, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the top college football picks the model is recommending for Championship Week: No. 4 Cincinnati (-10.5) covers against No. 21 Houston in the AAC Championship Game at 4 p.m. ET on Saturday. Cincinnati is one win away from possibly securing a spot as the first Group of Five team to ever make the College Football Playoff, but Houston has other ideas

The Cougars ride a hard-charging offense into this one, but they'll face a Cincinnati defense that has consistently been one of the best in the country all season. The Bearcats cover in 60 percent of simulations from SportsLine's model, making them a top pick for Championship Week college football. The point total, which sits at 53, goes over in over 50 percent of simulations as well.

Another one of the college football predictions from the model: No. 5 Oklahoma State (-5.5), fresh off a massive Bedlam win over rival Oklahoma, continues its roll and knocks off the No. 9 Baylor Bears in the Big 12 Championship Game at noon ET on Saturday. This is a rematch of an Oct. 2 matchup that Oklahoma State won 24-14, covering a four-point spread in that game. SportsLine's model is calling for a similar outcome in this matchup in Arlington, Texas.

Oklahoma State's stout defense holds Baylor to just 17 points in the simulations. The Cowboys score 27, giving them a comfortable double-digit victory. That helps them cover the spread almost 60 percent of the time. The under (46.5), meanwhile, hits in almost 60 percent of simulations. 

How to make Championship Week college football picks 

The model has also made the call on who wins and covers in every other game during the Championship Week college football schedule, and it's projecting multiple underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdogs do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Championship Week college football odds (via Caesars)

Here are the college football lines for Championship Week:

Friday, Dec. 3

Conference USA: Western Kentucky vs. UTSA (+1.5, 72)


Video: How Oklahoma State's Defense Can Lead Cowboys to Playoff (Stadium)

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Featured Game| UTSA Roadrunners vs. Western Kentucky Hilltoppers
Moneyline
Spread
Total
TXSA
+125
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+3
-110
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o72.5
-110
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WKY
-145
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-3
-110
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u72.5
-110
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Pac-12: Oregon vs. Utah (-2.5, 60)

Featured Game| Utah Utes vs. Oregon Ducks
Moneyline
Spread
Total
UTAH
-135
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-2.5
-115
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o58
-110
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OREG
+115
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+2.5
-105
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u58
-110
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Saturday, Dec. 4

MAC: Kent State vs. Northern Illinois (+3, 72.5)

Featured Game| Northern Illinois Huskies vs. Kent State Golden Flashes
Moneyline
Spread
Total
NILL
+140
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+3.5
-110
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o74.5
-110
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KENTST
-160
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-3.5
-110
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u74.5
-110
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Big 12: Baylor vs. Oklahoma State (-5.5, 46.5)

Featured Game| Oklahoma State Cowboys vs. Baylor Bears
Moneyline
Spread
Total
OKLAST
-220
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-5.5
-110
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o46.5
-110
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BAYLOR
+180
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+5.5
-110
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u46.5
-110
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Mountain West: Utah State vs. San Diego State (-6, 50.5)

Featured Game| San Diego State Aztecs vs. Utah State Aggies
Moneyline
Spread
Total
SDGST
-230
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-6
-110
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o50
-110
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UTAHST
+190
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+6
-110
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u50
-110
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Sun Belt: Appalachian State vs. Louisiana (+3, 52.5)

Featured Game| Louisiana Ragin' Cajuns vs. Appalachian State Mountaineers
Moneyline
Spread
Total
UL
+120
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+3
-110
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o53
-105
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APLST
-140
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-3
-110
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u53
-115
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SEC: Georgia vs. Alabama (+6.5, 50)

Featured Game| Alabama Crimson Tide vs. Georgia Bulldogs
Moneyline
Spread
Total
BAMA
+200
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+6.5
-110
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o49.5
-110
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UGA
-240
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-6.5
-110
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u49.5
-110
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AAC: Houston vs. Cincinnati (-10.5, 54)

Featured Game| Cincinnati Bearcats vs. Houston Cougars
Moneyline
Spread
Total
CINCY
-430
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-10.5
-110
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o53
-110
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HOU
+330
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+10.5
-110
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u53
-110
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ACC: Pittsburgh vs. Wake Forest (+3, 72.5)

Featured Game| Wake Forest Demon Deacons vs. Pittsburgh Panthers
Moneyline
Spread
Total
WAKE
+130
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+3
-110
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o71.5
-110
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PITT
-150
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-3
-110
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u71.5
-110
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Big Ten: Michigan vs. Iowa (+10.5, 43.5)

Featured Game| Iowa Hawkeyes vs. Michigan Wolverines
Moneyline
Spread
Total
IOWA
+350
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+11
-110
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o43.5
-110
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MICH
-450
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-11
-110
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u43.5
-110
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USC vs. California (-2.5, 57.5)

Featured Game| California Golden Bears vs. USC Trojans
Moneyline
Spread
Total
CAL
-180
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-4
-110
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o58
-110
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USC
+155
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+4
-110
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u58
-110
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